Working with Big Business
Big Business has lots of stakeholders and regulators who want to ensure all their activities are being performed legally (and hopefully ethically). This causes large bureaucracies to develop. This means dealing with big business can sometimes be similar to dealing with governments. There are processes and systems to follow that may not make sense to the small company. This can add to costs and frustrations.
Big companies usually have more flexibility to change when they spend their money and so often cope more easily with delays and schedule changes.